Tousled-like kinases (TLKs) are conserved serine/threonine kinases that orchestrate chromatin dynamics during DNA replication and repair. These enzymes transiently associate with histone chaperones ...

Translesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate ...

Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like ...

In our bodies, there are trillions of cells. From white blood cells to skin cells, each type has its own specific function which helps us perform tasks and survive. But what makes up these cells and ...

A team led by Professor Michal Hocek at IOCB Prague has explored the limits of the structure and function of DNA and successfully pushed forward known boundaries. Their latest research has just been ...

Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

Tiny tweaks in DNA folding can have big effects. A study from Umeå University shows that even the most subtle changes in DNA's shape have an important influence on gene activity and energy production.

A blue-and-gray 3D representation of a strand of DNA with other strands floating in the background. Google has officially released its AlphaGenome machine learning model, which can predict the ...