One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...

A team of researchers has successfully created more effective immune cells that can fight cancer without damaging healthy tissue. "This story goes back nearly 20 years," says Prof. Paul François. This ...

A detailed examination of V-J gene usage differences across cancer types revealed clear tissue-specific patterns (excluding LIHC hereafter due to limited sample size). The TRBV families exhibited ...

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...

T cell immunotherapies offer a new approach to cancer therapy. Chimeric antigen receptor (CAR) T cell therapy is the most prolific of these treatments, leveraging genetically engineered T cells to ...

Landau, MD, discussed promising results of CAR T-cell therapy in light chain amyloidosis and the challenge of developing ...

CAR-T therapy is a highly specialized treatment that requires careful patient selection and close monitoring. Some patients ...

Shared TCR signatures in IBD linked to HLA-DRB1 reveal common immune mechanisms across ulcerative colitis and Crohn’s disease ...

As of April 2025, four CD19-directed chimeric antigen receptor (CAR)-T therapies and three CD20-targeting bispecific antibodies (BsAbs) have been US Food and Drug Administration (FDA) approved for the ...

The gray portion of this schematic represents a nanodisc, where for the first time researchers were able to replicate the native membrane environment (red dots) of a T-cell receptor (cyan). One of the ...