In a recently published review, a research team led by MedUni Vienna has highlighted a promising new approach to drug discovery. The focus is on the targeted modulation of certain intracellular ...

Its origin from mitochondrial DNA suggests that it may function as part of a retrograde signaling system, where mitochondria ...

G-protein-coupled receptors (GPCRs) are the largest class of membrane receptors and key drug targets. Over the past decade, extensive evidence has shown that GPCRs signal from various intracellular ...

Designated areas (white circles) were irradiated with blue light at specific frequencies (indicated in the top left of each panel) to examine chemotactic aggregation. A research team led by Dr.

Metabolites are essential energy sources and building blocks for biosynthetic pathways 1. Traditionally, they were mainly thought to modulate metabolic pathways by directly influencing the activity of ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

One of the most important mechanisms is receptor-mediated signaling. A peptide attaches to a specific receptor on the cell surface, which then activates intracellular proteins such as kinases or ...