GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve ...

Researchers have found a protein that connects GLP-1 agonist drugs to long-term, broad genomic responses that can promote pancreatic health and resilience. GLP-1s are building a reputation as ‘wonder ...

When a gene is turned on in a cell, it creates a ripple effect along the DNA strand, changing the physical structure of the strand. A new study by MIT researchers, appearing in Science, shows that ...

DNA methylation is a key epigenome component that helps dictate how genes are expressed, contributing to normal cell and tissue differentiation during development, as well as the process of biological ...

Despite spanning about three billion base pairs, the human genome is wrapped up tight in a highly organized fashion in the nucleus. This coordinated structure, in part, enables the cell to regulate ...

Inside a diseased cell, the genes are in chaos. Some are receiving signals to overproduce a protein. Others are reducing activity to abnormal levels. Up is down and down is up. The right molecule ...

Diet can leave lasting epigenetic marks that reshape gene expression, metabolic pathways, and disease susceptibility across the lifespan. These diet-driven molecular changes may create a form of ...

If the genome is the blueprint of life, epigenetics is the control system that determines when, where, and how genes are expressed. By revealing how chemical modifications to DNA and chromatin shape ...

Small (left) and large (right) condensates of the Mediator complex inside nuclei of a pancreatic beta cell-derived cell line. Salk researchers discovered that GLP-1s interact with the multi-protein ...